abstract：BACKGROUND:Staurosporine (STS), a microbial alkaloid and potent PKC inhibitor, has become one of the most promising anti-cancer drugs. STS effectively induces apoptosis in many nucleated cells; however, it is still unclear whether STS induces apoptosis in enucleated platelets. METHODS:Apoptotic events in platelets tre...

journal_title：Clinical laboratory

authors： Zhao L,Lu G,Zhao Q,Zhang M,Chen M,Zhang J,Dai K

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The previous study has reported the association of hematocrit (HCT) with inflammation in several diseases. But the role of HCT in systemic lupus erythematosus (SLE) remained unclear. We tried to evaluate the clinical significance of HCT levels in patients with SLE. METHODS:A retrospective study including 12...

journal_title：Clinical laboratory

authors： Yang M,Ma N,Fu H,Wei T,Tang Q,Qin B,Yang Z,Zhong R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the relationship between serum CysC levels and high blood pressure (HBP) and to explore its diagnostic value for HBP in elder type 2 diabetic (T2D) population. METHODS:A total of 369 elder T2D patients (age > 60) were included in this cross-sectional study. Their cli...

journal_title：Clinical laboratory

authors： Gao P,Zhao K,Wang XM,Xiao H,Si LY,Li XJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:There is a high burden of both diabetes and tuberculosis in China. Diabetes depresses the immunologic response that facilitates the development of infectious diseases, including infection by Mycobacterium tuberculosis, the agent of tuberculosis. Tuberculosis is the third cause of death among subjects with no...

journal_title：Clinical laboratory

authors： Zhang X,Ma A,Sun S,Sun Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown some protective effects on brain ischemic injures in vivo and in vitro models. However, cotreatment with carbenoxolone (Cbx) and phosatidylinositol 3-kinase (PI3K) inhibitor LY 294002 to a focal cerebral ischemia and reperfusion rat model has not been studied yet. Her...

journal_title：Clinical laboratory

authors： Wang YK,Deng F,Miao J,Xie H,Feng JC

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) has been suggested to play an important role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The aim of this article is to explore the relationship between APPL1 rs4640525 polymorphism and th...

journal_title：Clinical laboratory

authors： Wang B,Wang B,Wang Y,Wen B,Liu S,Sang L,Chen Y,Zhang D

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To evaluate the diagnostic and prognostic value of sensitive troponin I (TnI) in patients with acute dyspnea and/or peripheral edema suspected of having acute heart failure (AHF). METHODS:This single centre prospective clinical study evaluates 372 patients presenting with acute dyspnea and/or peripheral ede...

journal_title：Clinical laboratory

authors： Behnes M,Espeter F,Hoffmann U,Lang S,Brueckmann M,Akin I,Borggrefe M,Bertsch T,Weiss C,Neumaier M,Ahmad-Nejad P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Hereditary tyrosinemia type 1 (HT1) is an autosomal recessive disease caused by a defect of fumarylacetoacetate hydrolase. This study aimed to estimate the prevalence of HT1 in Tunisia and report its clinical, biochemical and genetic features. METHODS:During the last 25 years, 69 patients were diagnosed wit...

journal_title：Clinical laboratory

authors： Nasrallah F,Hammami MB,Ben Rhouma H,Fradj SH,Azzouz H,Omar S,Feki M,Ben Youssef IT,Messaoud T,Tebib N,Kaabachi N

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Tissue microarrays (TMAs) extract designated areas of tissue paraffin blocks in several units that are millimeters in diameter in a cylindrical fashion, array dozens of these tissue specimens, and then re-embed them. Here, a TMA was utilized to analyze renal cell carcinoma (RCC) specimens with anti-FABP7 and...

journal_title：Clinical laboratory

authors： Fujita H,Takayama T,Takaoka N,Tan C,Igarashi H,Sugimura H,Ozono S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The UroVysion Bladder Cancer Kit requires morphological analysis of 4', 6-diamino-2-phenylindole (DAPI)-stained nuclei to identify target cells for fluorescence in situ hybridization (FISH) signals. Reproducibility and efficiency of target cell selection and counting was evaluated by combining immunofluoresc...

journal_title：Clinical laboratory

authors： Hattori S,Kikuchi A,Sawamura T,Daimaru O,Horie M,Deguchi T

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Typing of nosocomial pathogens is necessary to determine the source of an outbreak. The aim was to determine the genomic variability among Pseudomonas aeruginosa (P. aeruginosa) by random amplification of polymorphic DNA (RAPD) and enterobacterial repetitive intergenic consensus (ERIC) methods. METHODS:Fift...

journal_title：Clinical laboratory

authors： Valadbeigi H,Tabatabaei RR,Malek A,Sekawi Z,Raftari M,Parvaneh K,Ghafourian S,Sadeghifard N

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Previous studies revealed that the immune responses of depressed patients can be affected by alteration of immune system factors; however, the immune genes mainly influenced are yet to be fully understood. Therefore, the main aim of present study was to identify serum levels of drastic inflammatory cytokines...

journal_title：Clinical laboratory

authors： Momeni M,Ghorban K,Dadmanesh M,Hajebrahimi B,Khodadadi H,Hassanshahi G,Arababadi MK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Endocan is a marker of angiogenesis previously studied in various types of cancer and inflammatory conditions. Its expression is influenced by vascular endothelial growth factor A (VEGF A) and tumor necrosis factor alpha (TNF alpha), cytokines involved in pathogenetic pathways in inflammatory bowel disease (...

journal_title：Clinical laboratory

authors： Voiosu T,Bălănescu P,Benguş A,Voiosu A,Baicuş CR,Barbu M,Ladaru A,Nitipir C,Mateescu B,Diculescu M,Voiosu R

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Resistance to anti-platelet therapy whether defined by the laboratory detection of platelet function or the recurrence of cardiovascular events, has received extensive coverage in the literature coming predominantly from developed countries and very scanty information comes from developing countries. We aim ...

journal_title：Clinical laboratory

authors： Al Shamiri MQ,Abdel Gader AM,Bayoumy NM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Clonidine is commonly used as a calmative and antihypertensive agent in perioperative care. Due to the drug's alpha-2-agonistic effects, it has recently been hypothesised that clonidine may affect platelet aggregability. The present investigation aimed to study the potential impact of clonidine on the effica...

journal_title：Clinical laboratory

authors： Adam EH,Baro D,Schmidt P,Mutlak H,Zacharowski K,Hanke AA,Weber CF

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Clinical laboratory reference intervals (RIs) for serum complement C3 and C4 levels have been established in many countries but there is a lack of published data regarding normal RIs in Chinese population. We attempted to establish RIs for serum complement C3 and C4 levels in Chinese Han ethnic males. METHO...

journal_title：Clinical laboratory

authors： Qin X,Lu Y,Yang X,Peng Q,Wang J,Mo C,Wu J,Sui J,Liu Y,Huang X,Zhai L,Yang S,Li R,Li S,Yang X,Gao Y,Mo Z

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Vancomycin-resistant enterococci (VRE) are a serious problem all over the world. The present study was conducted to investigate antimicrobial resistance patterns, genotypes, clonal relationship, and virulence fac- tors of VRE species isolated from rectal swab samples of hospitalized patients, patient's relat...

journal_title：Clinical laboratory

authors： Cakirlar FK,Samasti M,Baris I,Kavakli H,Karakullukcu A,Sirekbasan S,Bagdatli Y

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Prostate cancer (PCa) represents the most commonly diagnosed type of malignancy among men in Western European countries and the second cause of cancer-related deaths among men worldwide. Methylation of the CpG island has an important role in prostate carcinogenesis and progression. The purpose of the study w...

journal_title：Clinical laboratory

authors： Dumache R,Puiu M,Motoc M,Vernic C,Dumitrascu V

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Anaerobic bacteria play an important role in eye infections; however, there is limited epidemiologic data based on the the role of these bacteria in the etiology of keratitis and endophthalmitis. The aim of this re- search is to determine the prevalence of anaerobic bacteria in perforated corneal ulcers of p...

journal_title：Clinical laboratory

authors： Tokman HB,İskeleli G,Dalar ZG,Kangaba AA,Demirci M,Akay HK,Borsa BA,Algingil RÇ,Kocazeybek BS,Torun MM,Kiraz N

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV) is a serious risk factor for several severe liver diseases such as cirrhosis and hepatocellular carcinoma. HBV, like other viruses, uses several mechanisms to escape from specific immune responses including the use of mutations in the genome which lead to epitope variations. There are...

journal_title：Clinical laboratory

authors： Zare-Bidaki M,Ayoobi F,Hassanshahi G,Arababadi MK,Mirzaei T,Darehdori AS,Kennedy D

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Haemolysis is usually caused by inadequate specimen collection or preanalytical handling and is suggested to be a suitable indicator of preanalytical quality. We investigated the prevalence of detectable haemolysis in all routine venous blood samples in OPDs and IPDs to identify differences in preanalytical ...

journal_title：Clinical laboratory

authors： Ahmad MI,Ramesh KL,Kumar R

更新日期：2014-01-01 00:00:00

abstract：:Herbs have been used for centuries to prevent and control many diseases. The biggest challenge and problem is lack of information about the effect of herbs and its side effects. Thyme (thymus vulgaris) is a small shrubby plant with a strong, spicy taste, and odor. Thyme has carminative, diaphoretic, expectorant, sedat...

journal_title：Clinical laboratory

authors： Erol S,Aydin B,Dilli D,Okumuş N,Zenciroğlu A,Gündüz M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Periodontitis is a chronic multifactorial inflammatory disease caused by microorganisms and characterized by progressive destruction of the tooth supporting tissues leading to tooth loss. Periodontal diseases are associated with an increase in CRP (C-reactive protein) levels. Release of the cytokines such as...

journal_title：Clinical laboratory

authors： Baser U,Oztekin G,Ademoglu E,Isik G,Yalcin F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The identification of prothrombin G20210A polymorphism (PT20210) is normally included in the thrombophilia laboratory panel and evaluated by DNA-based molecular analysis. To date, a routine coagulation test that helps to identify PT20210 carriers has not been set, in contrast to the FV Leiden mutation, for w...

journal_title：Clinical laboratory

authors： Rolla R,Pergolini P,Vidali M,Pollarolo P,Appiani A,Cerutti C,Manzini M,Crisci A,Bellomo G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes mellitus (T2DM) is a serious threat to human health and remains incurable. Insulin deficiency seems to be attributed to the progressive failure of pancreatic islet β-cells and immune cells such as T cells mediated cytotoxicity may be involved in the loss of pancreatic islet β-cells in T2DM. T...

journal_title：Clinical laboratory

authors： Kong D,Zhuang X,Wang D,Qu H,Jiang Y,Li X,Wu W,Xiao J,Liu X,Liu J,Li A,Wang J,Dou A,Wang Y,Sun J,Lv H,Zhang G,Zhang X,Chen S,Ni Y,Zheng C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Neurosyphilis diagnosis is frequently dependent upon the results of serological tests and cerebrospinal fluid abnormalities, but the reliability of findings in patients with HIV-1 infection has been questioned, especially in asymptomatic patients with latent syphilis. In this study, we present the data on th...

journal_title：Clinical laboratory

authors： Fraga D,Muller AL,Czykiel MS,De Armas Y,Wissmann G,Goldani LZ

更新日期：2014-01-01 00:00:00

abstract：:As the post-genome era comes, one of the trends of future medical developments is the timely diagnosis and prevention of diseases. The analysis of nucleic acid can diagnose the diseases accurately at gene level which can eliminate all kinds of false positive and negative results from phenotype and prescribe the indivi...

journal_title：Clinical laboratory

authors： Lian DS,Zhao SJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The aim of this multicenter study was to establish a diagnostic algorithm using molecular methods for the diagnosis of C. difficile-associated infection (CDI). In addition patient specific data were taken into consideration for the interpretation of the results. METHODS:We compared the performance of six di...

journal_title：Clinical laboratory

authors： Eigner U,Fenner I,Veldenzer A,Schwarz R,Oberdorfer K,Holfelder M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:It has been shown that serum concentrations of 1,25(OH)2D3 are decreased in patients with gout. A short-term administration of allopurinol increases plasma concentrations of 1,25(OH)2D3 in mild to moderate renal failure, with or without hyperuricemia. It has been reported that subjects who perform regular vi...

journal_title：Clinical laboratory

authors： Sanchis-Gomar F,Salvagno GL,Lippi G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The aim was to calculate the two-sided 95th percentile reference values for blood urea nitrogen (BUN) and serum creatinine (SCr) in Chinese Han ethnic adult men. METHODS:Serum samples were collected from Chinese Han ethnic adult men aged 20 - 69 years. After screening based on the inclusion and exclusion cr...

journal_title：Clinical laboratory

authors： Huang X,Li S,Yang X,Peng Q,Wang J,Mo C,Wu J,Sui J,Liu Y,Lu Y,Deng Y,Xie L,Li T,He Y,Gao Y,Mo Z,Yang X,Qin X

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Acne vulgaris is one of the most common skin conditions affecting young adults. The relationship between lipid profile or lipid ratios and acne is not widely reported. METHODS:A case control study was performed in 90 females with severe acne vulgaris. Lipid profiles were measured, lipid ratios were calculat...

journal_title：Clinical laboratory

authors： Arora MK,Seth S,Dayal S,Trehan AS,Seth M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:We aimed to show sensitivity and specificity of NT-ProBNP in demonstrating the degree of cardiac failure caused by dilated cardiomyopathy (DCMP). METHODS:From January 2006 to July 2012, thirty patients (2 - 168 months) who had DCMP with acute heart failure and 37 healthy children aged (1 - 168 months) were ...

journal_title：Clinical laboratory

authors： Narin N,Hekimoglu B,Baykan A,Ozyurt A,Zararsiz G,Sezer S,Onan SH,Argun M,Pamukcu O,Uzum K

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Cancer antigen-125 is a high molecular weight glycoprotein used mainly for the diagnosis of ovarian carcinoma. However, elevation of cancer antigen-125 is observed in many benign conditions specially in liver cirrhosis but the reason behind the elevation remains unknown. Similarly intercellular adhesion mole...

journal_title：Clinical laboratory

authors： Chowdhury MA,Xiubin Z,Wei H,Chenghao G

更新日期：2014-01-01 00:00:00

abstract：:The transfusion efficacy of ATK, which contain fully functional platelets, is beyond all doubt. The equivalence of ATK and PTK has been subject of many studies. Some of those studies show the superiority of ATK's, while others do not, but there have been no studies that demonstrated a superiority of PTK's. The superio...

journal_title：Clinical laboratory

authors： Hitzler WE

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) and calculation of a kappa/lambda ratio using polyclonal antisera based immunoassays provide laboratories with a sensitive alternative to urine protein electrophoresis (UPE). However, the published 0.26 - 1.65 serum FLC kappa/lambda ratio reference intervals ma...

journal_title：Clinical laboratory

authors： Liang YF,Chen WM,Wang QT,Zhai YH,Yang YJ,Liu JY,Levoguer A,Sun WH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Persistent infection by HPV is now recognized as the main cause of cervical cancer. HPV prevalence data is not yet available in Iran. This study is organized to evaluate type-specific HPV prevalence and to compare it with Pap smear results among Iranian women attending regular gynecological visits. METHODS:...

journal_title：Clinical laboratory

authors： Yousefzadeh A,Mostafavizadeh SM,Jarollahi A,Raeisi M,Garshasbi M,Siavashvahabi Z,Moazzami B,Shafaghi B

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Further use of reagents, that have not been consumed in total by tests in the laboratory, is of financial and ecological interest. If there are no instructions by the manufacturer, such a procedure must be validated thoroughly. As gelcards of the DiaMed-ID Micro Typing System contain 6 microtubes for immunoh...

journal_title：Clinical laboratory

authors： Strobel E,Betten S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The object of the study was to estimate the possible economic effects of a sequential testing strategy with NT-proBNP from a primary care payer perspective. METHODS:The study data were collected from primary care physicians in the County of Uppland from 2005 through 2012. Two different cut-off levels were u...

journal_title：Clinical laboratory

authors： Khezri BS,Helmersson-Karlqvist J,Larsson A

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Soluble receptor for advanced glycation end products (sRAGE) acts as a decoy receptor for RAGE which has several distinct pro-inflammatory ligands in the extracellular compartment, and is believed to afford protection against inflammation and cell injury. This study was conducted to measure serum sRAGE in as...

journal_title：Clinical laboratory

authors： El-Seify MY,Fouda EM,Nabih ES

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:A high-performance liquid chromatographic (HPLC) assay for vitamin B6 in human serum was compared with a novel microbiological assay (ID-Vit) that uses microtitre plates precoated with a specific microorganism, thus avoiding numerous problems associated with the use of stock cultures utilized by common other...

journal_title：Clinical laboratory

authors： Loitsch SM,Reuter KC,Oremek GM,Wetzstein R,Stangl K,Armbruster FP,Dschietzig TB,Stein J

更新日期：2014-01-01 00:00:00